Publications

≤ 2025

  1. Pinals, R. L.†*, Islam, M. R.†*, King, O., Choi, A., Kang, E., Nakano, M., Tuyéras, A., Naomi, M. T., Ngo, A., Jiang, A., Truong, N., Agbas, E., Lozano Cruz, C. F., Staab, C., Ko, T., Bennett, D. A., Stanton, A. E., Langer, R., and Tsai, L.-H.* Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s disease. Submitted (2025).

    † Equal contribution

    * Co-corresponding author

  2. Stanton, A. E.†*, Pinals, R. L.†*, Choi, A., Truong, N., Kang, E., Jiang, A., Lozano Cruz, C. F., Hawkins, S., Sarcar, R., Volkova, A., King, O., Agbas, E., Nakano, M., Chiu, C.-C., Bubnys, A., Wright, S., Staab, C., Bikdash, R., Forden, E., Langer, R.*, and Tsai, L.-H.* Human Neuro-Immuno-Glial-Vascular Brain-on-Chip with Functionally Perfusable Vasculature. Submitted (2025).

    † Equal contribution

    * Co-corresponding author

  3. Voke, E., Arral, M. L., Squire, H. J., Lin, T. J., Coreas, R., Lui, A., Iavarone, A. T., Pinals, R. L.*, Whitehead, K. A.*, and Landry, M. P.* Protein Corona Formed on Lipid Nanoparticles Compromises Delivery Efficiency of mRNA Cargo. Accepted at Nature Communications (2025).
    * Co-corresponding author

  4. Stanton, A. E.†*, Bubnys, A.†, Agbas, E., James, B., Park, D.-S., Jiang, A., Pinals, R. L., Truong, N., Loon, A., Staab, C., Liu, L., Cerit, O., Wen, H.-L., Kellis, M., Blanchard, J. W.*, Langer, R. S.*, and Tsai, L.-H.* Engineered 3D Immuno-Glial-Neurovascular Human Brain Model. Accepted at PNAS (2025).

  5. Rosenberg, D. J., Cunningham, F. J., Hubbard, J. D., Goh, N. S., Wang, J. W., Hayman, E., Hura, G. L., Landry, M. P., and Pinals, R. L.* Mapping the Morphology of DNA on Carbon Nanotubes in Solution using X-ray Scattering Interferometry. J. Am. Chem. Soc. 146, 386–398 (2024).
    * Corresponding author

  6. Rostami, M. W., Bannish, B. E., Gasior, K., Pinals, R. L., Dawes, A. T., and Copos, C.* Inferring Local Molecular Dynamics from the Global Actin Network Structure: a Case Study of 2D Synthetic Branching Actin Networks. J. Theor. Biol. 575, 111613 (2023).

  7. Pinals, R. L. and Tsai, L. H.* Building In Vitro Models of the Brain to Understand the Role of APOE in Alzheimer’s Disease. Life Sci. Alliance 5 (2022).

  8. Pinals, R. L.†, Ouassil, N.†, Bonis-O’Donnell, J. T. D., Wang, J. W., and Landry, M. P.* Supervised Learning Model Predicts Protein Adsorption to Nanotubes. Sci. Adv. 8, eabm0898 (2022).

    † Equal contribution

  9. Zhang, H.†, Goh, N. S.†, Wang, J., Pinals, R. L., González-Grandío, E., Demirer, G. S., Butrus, S., Fakra, S. C., Del Rio Flores, A., Zhai, R., Zhao, B., Park, S. J., and Landry, M. P.* Nanoparticle Cellular Internalization is Not Required for RNA Delivery to Mature Plant Leaves. Nat. Nanotechnol. 17, 197–205 (2022).

  10. Fung, F. M.*, Jilani, S. Z.*, Ohnsorg, M. L.*, Pinals, R. L.*, Saraf, M.*, Tropp, J.+, and Carlton, P. How Early-Career Scientists Responded with Resiliency to the Space Created by the COVID-19 Pandemic. ACS Cent. Sci. 8, 294–296 (2022).

  11. Pinals, R. L., Ledesma, F., Yang, D., Navarro, N., Jeong, S., Pak, J. E., Kuo, L., Chuang, Y. C., Cheng, Y. W., Sun, H. Y., and Landry, M. P.* Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Lett. 21, 2272–2280 (2021).

  12. Voke, E., Pinals, R. L., Goh, N. S., and Landry, M. P.* In Planta Nanosensors: Understanding Biocorona Formation for Functional Design. ACS Sens. 6, 2802–2814 (2021).

  13. Jeong, S., Grandio, E. G., Navarro, N., Pinals, R. L., Ledesma, F., Yang, D., and Landry, M. P.* Extraction of Viral Nucleic Acids with Carbon Nanotubes Increases SARS-CoV-2 Quantitative Reverse Transcription Polymerase Chain Reaction Detection Sensitivity. ACS Nano 15, 10309–10317 (2021).

  14. Copos, C., Bannish, B.†, Gasior, K.†, Pinals, R. L.†, Rostami, M. W.†, and Dawes, A.* Connecting Actin Polymer Dynamics across Multiple Scales. In: Segal R., Shtylla B., Sindi S. (eds). Using Mathematics to Understand Biological Complexity: From Cells to Populations. Springer AWM Series (2021).

    † Equal contribution

  15. Pinals, R. L., Yang, D., Rosenberg, D. J., Chaudhary, T., Crothers, A. R., Iavarone, A. T., Hammel, M., and Landry, M. P.* Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments. Angew. Chem. Int. Ed. 59, 23668–23677 (2020).

  16. Pinals, R. L.†, Yang, D.†, Lui, A., Cao, W., and Landry, M. P.* Corona Exchange Dynamics on Carbon Nanotubes by Multiplexed Fluorescence Monitoring. J. Am. Chem. Soc. 142, 1254–1264 (2020).

    † Equal contribution

  17. Pinals, R. L., Chio, L., Ledesma, F., and Landry, M. P.* Engineering at the Nano-Bio Interface: Harnessing the Protein Corona towards Nanoparticle Design and Function. Analyst 145, 5090–5112 (2020).

  18. Pinals, R. L.†, Jeong, S.†, Dharmadhikari, B., Song, H., Kalluri, A., Debnath, D., Wu, Q., Ham, M., Patra, P.*, and Landry, M. P.* Graphene Quantum Dot Oxidation Governs Noncovalent Biopolymer Adsorption. Sci. Rep. 10, 1–14 (2020).

    † Equal contribution

  19. Chio, L., Pinals, R. L., Murali, A., Goh, N. S., and Landry, M. P.* Covalent Surface Modification Effects on Single-Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging. Adv. Funct. Mater. 30, 1910556 (2020).

  20. Demirer, G. S., Zhang, H., Goh, N. S., Pinals, R. L., Chang, R., and Landry, M. P.* Carbon Nanocarriers Deliver siRNA to Intact Plant Cells for Efficient Gene Knockdown. Sci. Adv. 6, eaaz0495 (2020).

  21. Yang, D., Yang, S. J., Bonis-O’Donnell, J. T. D., Pinals, R. L., and Landry, M. P.* Mitigation of Carbon Nanotube Neurosensor Induced Transcriptomic and Morphological Changes in Mouse Microglia with Surface Passivation. ACS Nano 14, 13794–13805 (2020).

  22. Alizadehmojarad, A. A., Zhou, X., Beyene, A. G., Chacon, K. E., Sung, Y., Pinals, R. L., Landry, M. P.*, and Vuković, L.* Binding Affinity and Conformational Preferences Influence Kinetic Stability of Short Oligonucleotides on Carbon Nanotubes. Adv. Mater. Interfaces 7, 2000353 (2020).

  23. Del Bonis-O’Donnell, J. T., Pinals, R. L., Jeong, S., Thakrar, A., Wolfinger, R. D., and Landry, M. P.* Chemometric Approaches for Developing Infrared Nanosensors To Image Anthracyclines. Biochemistry 58, 54–64 (2018).

  24. Beyene, A. G., McFarlane, I. R., Pinals, R. L., and Landry, M. P.* Stochastic Simulation of Dopamine Neuromodulation for Implementation of Fluorescent Neurochemical Probes in the Striatal Extracellular Space. ACS Chem. Neurosci. 8, 2275–2289 (2017).

  25. Anderson, R. T., Zang, X., Fernando, R., Dzara, M. J., Ngo, C., Sharps, M. C., Pinals, R. L., Pylypenko, S., Lusk, M. T., and Sellinger, A.* Direct Conversion of Hydride to Siloxane Terminated Silicon Quantum Dots. J. Phys. Chem. C 120, 25822–25831 (2016).

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